Tyler Harmon Group – RTG 3120 Biomolecular Condensates https://dresdencondensates.org From Physics to Biological Functions Thu, 11 Sep 2025 13:01:15 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 https://dresdencondensates.org/wp-content/uploads/2022/01/cropped-Icon-32x32.jpg Tyler Harmon Group – RTG 3120 Biomolecular Condensates https://dresdencondensates.org 32 32 Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates https://dresdencondensates.org/impact-of-coiled-coil-domains-on-the-phase-behavior-of-biomolecular-condensates/ https://dresdencondensates.org/impact-of-coiled-coil-domains-on-the-phase-behavior-of-biomolecular-condensates/#respond Wed, 20 Aug 2025 12:35:44 +0000 https://dresdencondensates.org/?p=1942 A new Study from the Harmon and Sommer Labs in ACS Macro Letters entitled ‘Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates’ addressed how the geometry and structure of folded domains impact condensate formation. They used coarse-grained simulations to determine that coiled-coil domains (CCDs) promote liquid–liquid phase separation (LLPS), while replacing the CCD with a flexible linker abolishes LLPS. CCDs must have a critical length to promote LLPS at low concentrations.

The results of this study offer a framework for designing synthetic condensates with tunable phase behaviors.

Figure for paper "Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates"
© 2025 American Chemical Society

Citation:

Zhouyi He, Jens-Uwe Sommer, and Tyler S. Harmon. Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates. ACS Macro Letters 2025 14 (4), 413-419. DOI: 10.1021/acsmacrolett.4c00821

 

]]> https://dresdencondensates.org/impact-of-coiled-coil-domains-on-the-phase-behavior-of-biomolecular-condensates/feed/ 0 Molecular Assembly Lines in Active Droplets https://dresdencondensates.org/molecular-assembly-lines-in-active-droplets/ https://dresdencondensates.org/molecular-assembly-lines-in-active-droplets/#respond Wed, 30 Nov 2022 18:08:37 +0000 https://dresdencondensates.org/?p=1067

 

Cells assemble structures that have lots of molecules. How can such complicated structures be reliably assembled? We propose that cells could be organizing an assembly line process for the construction. We show how this could be organized inside droplets. In this video we explain our recent work published in PRL. Check out the paper for more info: https://journals.aps.org/prl/abstract…

Prepared by Mariona Esquerda Ciutat from the Hyman and Jülicher labs in Dresden.

 

]]> https://dresdencondensates.org/molecular-assembly-lines-in-active-droplets/feed/ 0 New Study: A multi-step nucleation process determines the kinetics of prion-like domain phase separation https://dresdencondensates.org/new-study-a-multi-step-nucleation-process-determines-the-kinetics-of-prion-like-domain-phase-separation/ https://dresdencondensates.org/new-study-a-multi-step-nucleation-process-determines-the-kinetics-of-prion-like-domain-phase-separation/#respond Fri, 18 Feb 2022 15:55:20 +0000 https://dresdencondensates.org/?p=706 In this study, time-resolved small-angle X-ray scattering (SAXS) was used to characterize liquid-liquid phase separation of Prion-like domains. Read more

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