A role for RNA in Stress Granules assembly

The Alberti, Guck, Honigmann, and Hyman labs published a study highlighting the role of RNA in the assembly of stress granules by crosslinkinig with G3BP clusters and how G3BP clusters in return prevent RNA entanglement. The research is published in cell.

Stress granules are membraneless compartments formed by phase separation of specific molecules upon exposure to cellular stress such as oxidative stress, heat shock, or osmotic stress.