Alberti Archives - RTG 3120 Biomolecular Condensates https://dresdencondensates.org/tag/alberti/ From Physics to Biological Functions Tue, 28 Apr 2026 13:03:21 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://dresdencondensates.org/wp-content/uploads/2022/01/cropped-Icon-32x32.jpg Alberti Archives - RTG 3120 Biomolecular Condensates https://dresdencondensates.org/tag/alberti/ 32 32 Alberti and Hyman among Clarivate’s Highly Cited Researchers in 2025 https://dresdencondensates.org/jahnel-alberti-and-hyman-among-clarivates-highly-cited-researchers-in-2025/ https://dresdencondensates.org/jahnel-alberti-and-hyman-among-clarivates-highly-cited-researchers-in-2025/#respond Thu, 13 Nov 2025 08:04:48 +0000 https://dresdencondensates.org/?p=2365   RTG 3120 PI’s have been among the most highly cited authors in 2025, according to Clarivate. The Hyman and […]

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RTG 3120 PI’s have been among the most highly cited authors in 2025, according to Clarivate. The Hyman and Alberti groups lead the way “in the top 1% by citations for their field(s) and publication year in the Web of Science Core Collection”

See the press release by TU Dresden: https://tu-dresden.de/tu-dresden/newsportal/news/starkes-zeichen-fuer-die-qualitaet-der-spitzenforschung-13-forschende-der-tud-gehoeren-zu-den-meistzitierten-weltweit?set_language=en

See the full list: https://clarivate.com/highly-cited-researchers/ 

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]]> https://dresdencondensates.org/jahnel-alberti-and-hyman-among-clarivates-highly-cited-researchers-in-2025/feed/ 0 Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates https://dresdencondensates.org/intra-condensate-demixing-of-tdp-43-inside-stress-granules-generates-pathological-aggregates/ https://dresdencondensates.org/intra-condensate-demixing-of-tdp-43-inside-stress-granules-generates-pathological-aggregates/#respond Wed, 20 Aug 2025 13:15:24 +0000 https://dresdencondensates.org/?p=1946 A new study from the labs of Honigmann, Hyman, and Alberti in Dresden, in addition to colleagues in Texas A&M […]

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]]> A new study from the labs of Honigmann, Hyman, and Alberti in Dresden, in addition to colleagues in Texas A&M University, Mayo Clinic, Brown University, and Saint Louis University investigates the mechanism behind pathological outcomes of protein aggregation inside stress granules. The authors of the study entitled “Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates” and published in Cell in May, 2025, determined that aggregation of TAR DNA-binding protein 43 (TDP-43) is induced by two events, namely up-concentration of TDP-43 in stress granules beyond a threshold and oxidative stress and described the mechanism behind the observation. They use this new understanding to engineer TDP-43 variants resistant to aggregation in the cell.

Impact: The aggregation of TDP-43 in motor neurons  is a hallmark of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Understanding the mechanisms leading to aggregation paves the path towards developing preventive and therapeutic strategies.

Graphical Abstract to paper 'Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates'
© 2025 The Author(s). Published by Elsevier Inc.

Citation:

Yan, X., Kuster, D., Mohanty, P., Nijssen, J., Pombo-García, K., Garcia Morato, J., Rizuan, A., Franzmann, T. M., Sergeeva, A., Ly, A. M., Liu, F., Passos, P. M., George, L., Wang, S.-H., Shenoy, J., Danielson, H. L., Ozguney, B., Honigmann, A., Ayala, Y. M., Fawzi, N. L., Dickson, D. W., Rossoll, W., Mittal, J., Alberti, S., & Hyman, A. A. (2025). Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates. Cell, 188(15), 4123-4140.e4118. https://doi.org/10.1016/j.cell.2025.04.039

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