Building a synthetic centrosome

The centrosome is a structure in cells which is built every time the cell prepares to divide. In this video abstract, Jeff Woodruff explains how to build a centrosome in a test tube from purified proteins. He found that the centrosome acts like a sponge, which selectively soaks up the proteins needed to build microtubules.

Read more in the full paper, published in the journal Cell: http://www.cell.com/cell/fulltext/S00…

See the full blog post at: http://www.sciencesketches.org/single…

Jeff Woodruff is a postdoc in the lab of Tony Hyman (hymanlab.org) at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany

Regulation of centrosome assembly by phosphorylation

In this video abstract, Oliver Wueseke tells you about his recent publication in Biology Open, “Polo-like kinase phosphorylation determines C.elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation,”

Learn more in the full paper Wueseke et al. (2016) http://dx.doi.org/10.1242/bio.020990

Written and narrated by Oliver Wueseke, illustrated by Jeff Woodruff, edited and produced by Lisa Dennison.

Centrosome Assembly

Hyman lab postdoc Jeff Woodruff describes the great unknowns of centrosome assembly and his plan of attack. Written and narrated by Jeff Woodruff. Produced by Lisa Dennison.