Coiled-Coil Domains – RTG 3120 Biomolecular Condensates https://dresdencondensates.org From Physics to Biological Functions Thu, 11 Sep 2025 13:01:15 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 https://dresdencondensates.org/wp-content/uploads/2022/01/cropped-Icon-32x32.jpg Coiled-Coil Domains – RTG 3120 Biomolecular Condensates https://dresdencondensates.org 32 32 Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates https://dresdencondensates.org/impact-of-coiled-coil-domains-on-the-phase-behavior-of-biomolecular-condensates/ https://dresdencondensates.org/impact-of-coiled-coil-domains-on-the-phase-behavior-of-biomolecular-condensates/#respond Wed, 20 Aug 2025 12:35:44 +0000 https://dresdencondensates.org/?p=1942 A new Study from the Harmon and Sommer Labs in ACS Macro Letters entitled ‘Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates’ addressed how the geometry and structure of folded domains impact condensate formation. They used coarse-grained simulations to determine that coiled-coil domains (CCDs) promote liquid–liquid phase separation (LLPS), while replacing the CCD with a flexible linker abolishes LLPS. CCDs must have a critical length to promote LLPS at low concentrations.

The results of this study offer a framework for designing synthetic condensates with tunable phase behaviors.

Figure for paper "Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates"
© 2025 American Chemical Society

Citation:

Zhouyi He, Jens-Uwe Sommer, and Tyler S. Harmon. Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates. ACS Macro Letters 2025 14 (4), 413-419. DOI: 10.1021/acsmacrolett.4c00821

 

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