6. April 2023
CD-Code is now published in Nature Methods
CD-CODE is now published in Nature Methods. It is a “living database” that we designed for fast addition and review of information about condensates and proteins and is open to users and expert researchers who would like to contribute. Join us and visit cd-code! CD code has been a…
30. November 2022
A quick intro to the Phase Diagram
Phase Diagrams are graphic representations that help understand many physical systems such as magnets and pure substances like water. These diagrams also help us understand how dense droplets of biomolecules, called Biomolecular Condensates, form inside cells. Phase Diagrams predict under which…
12. January 2022
A role for RNA in Stress Granules assembly
Stress granules are membraneless compartments formed by phase separation of specific molecules upon exposure to cellular stress such as oxidative stress, heat shock, or osmotic stress. The Alberti, Jahnel, Honigmann, and Hyman labs published a study in cell highlighting the role of RNA in the…
10. January 2022
Condensation regulates translation
New insights into the influence of Ded1p condensation on translation comes from the Hyman, Alberti and Kreysing labs. The study published in Cell is entitled "Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production". Graphical abstract: Abstract: Cells…
2. July 2019
Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes
The Diez and Hyman labs, in collaboration with the Lansky and Braun lab at the Institute of Biotechnology of the Czech Academy of Sciences, Czech Republic, published a study on the role of phase separation of the intrinsically disordered Tau protein in regulating the activity of motor proteins and…
5. September 2017
Local nucleation of microtubule bundles through tubulin concentration into a condensed tau phase
Theskeleton that supports the structure of our cells, termed cytoskeleton is formed of several kinds of polymers including actin and microtubules. How the single units on the polymers (monomers and dimers) are concentrated to gether to synthesize the polymer is the subject of this study by the labs…