Current news by our research groups

We’re currently hiring!

We’re looking for Master and PhD students. Get in touch if you love epigenetics, genomics, and long-read sequencing as much as we do! Especially if you have an affinity not only for molecular biology but also for bioinformatics! Students interested in a PhD project should apply to the Dresden…

Alf Honigmann Group,Anthony Hyman Group,Marcus Jahnel Group,Simon Alberti Group

A role for RNA in Stress Granules assembly

Stress granules are membraneless compartments formed by phase separation of specific molecules upon exposure to cellular stress such as oxidative stress, heat shock, or osmotic stress. The Alberti, Jahnel, Honigmann, and Hyman labs published a study in cell highlighting the role of RNA in the…

Simon Alberti Group

Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells

Aminoacyl-tRNA synthetases (aaRSs), the enzymes responsible for coupling tRNAs to their cognate amino acids, minimize translational errors by intrinsic hydrolytic editing. Here, we compared norvaline (Nva), a linear amino acid not coded for protein synthesis, to the proteinogenic, branched valine…

Moritz Kreysing Group

Regulated changes in material properties underlie centrosome disassembly during mitotic exit

Simon Alberti Group,Anthony Hyman Group,Moritz Kreysing Group

Condensation regulates translation

New insights into the influence of Ded1p condensation on translation comes from the Hyman, Alberti and Kreysing labs. The study published in Cell is entitled "Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production". Graphical abstract: Abstract: Cells…

Learn the basics of Biomolecuar Condensates

How do single molecules move in and out of condensates?

Science Sketches,Advanced

24. February 2023

by Mariona Esquerda Ciutat

0 Comments1 Minute

A quick intro to Complexity

Science Sketches,Intro

15. February 2023

by Mohamad Almedawar

0 Comments1 Minute

A quick intro to Irreversibility

Science Sketches,Intro

2. February 2023

by Mohamad Almedawar

0 Comments1 Minutes

Go to the Science Sketches page for more cool explanatory movies.

Stefan Diez Group at B CUBE (TU Dresden)

Remodeling enzymes set up the canonical nucleosome organization of genes.

In an ATP hydrolysis-dependent manner, remodelers open up a “nucleosome depleted region” (NDR) and generate an array of nucleosomes with even spacing downstream of the transcription start site (arrow; bottom). Without remodelers (top), cryptic promoters open up leading to spurious transcription. Picture credits: Felix Mueller-Planitz