Expertise

The Adams group has a strong background in physical chemistry and soft matter physics, utilizing spectroscopic methods. Key research topics include solvation dynamics, specific ion effects, and protein-water interactions1. In recent years, the group has developed spectroscopic methods for probing the solvent environment in biomolecular condensates, which revealed that release of hydration water is an entropic driving force for liquid-liquid phase separation1,2.

References:
  1. Adams EM, Pezzotti S, Ahlers J, Rüttermann M, Levin M, Goldenzweig A, Peleg Y, Fleishman SJ, Sagi I, Havenith M. Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction. JACS Au. 2021;1(7):1076-1085. https://doi.org/10.1021/jacsau.1c00155
  2. Ahlers J, Adams EM, Bader V, Pezzotti S, Winklhofer KF, Tatzelt J, Havenith M. The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUS. Biophys J. 2021;120(7):1266-1275. https://doi.org/10.1016/j.bpj.2021.01.019

The stripping away of less favorable hydration water drives the liquid-liquid phase separation of intrinsically disordered proteins, leading to a constrained hydration environment within the phase separated condensates

Current news by this research group

Join the Adams Group as a PhD Student (m/f/d) to study the role of

The Adams group has an opening for a PhD student for the following project: Prevention of Intrinsically Disordered Protein Aggregation with Solvent Tuning: Unraveling the Role of Water in Condensate Aging Preferred Course of Study/Expertise of Candidate: Molecular Biology, Biochemistry, Chemistry,…

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Physics of Life Excellence Postdoctoral Fellowships

Join research groups at the Physics of Life (PoL) as a postdoc by applying to a PoL Excellence Postdoctoral Fellowship and benefit from up to 4-year funded position in association with PoL groups and the Mentorship program. Applicants should hold a PhD in Physics, Biology or related fields (at the…

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The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUS

What drives the formation of biomolecular condensates from proteins in water? The Adams group, in collaboration with colleagues from Ruhr-University Bochum, Germany, measured the thermodynamic forces leading to the expulsion of water from condensates as they form through protein-protein…

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