Publication YearTitleAuthorsJournal/BookDOI
2025SUMO2/3 conjugation of TDP-43 protects against aggregationVerde EM, Antoniani F, Mediani L, Secco V, Crotti S, Ferrara MC, Vinet J, Sergeeva A, Yan X, Hoege C, Stuani C, Paron F, Kao TT, Shrivastava R, Polanowska J, Bailly A, Rosa A, Aronica E, Goswami A, Shneider N, Hyman AA, Buratti E, Xirodimas D, Franzmann TM, Alberti S, Carra S.Sci Advhttps://doi.org/10.1126/sciadv.adq2475
2025G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatabilityTrussina IREA, Hartmann A, Desroches Altamirano C, Natarajan J, Fischer CM, Aleksejczuk M, Ausserwöger H, Knowles TPJ, Schlierf M, Franzmann TM, Alberti S.Mol Cellhttps://doi.org/10.1016/j.molcel.2024.11.039
2025Small-molecule dissolution of stress granules by redox modulation benefits ALS modelsUechi H, Sridharan S, Nijssen J, Bilstein J, Iglesias-Artola JM, Kishigami S, Casablancas-Antras V, Poser I, Martinez EJ, Boczek E, Wagner M, Tomschke N, de Jesus Domingues AM, Pal A, Doeleman T, Kour S, Anderson EN, Stein F, Lee HO, Zhang X, Fritsch AW, Jahnel M, Fürsch J, Murthy AC, Alberti S, Bickle M, Fawzi NL, Nadler A, David DC, Pandey UB, Hermann A, Stengel F, Davis BG, Baldwin AJ, Savitski MM, Hyman AA, Wheeler RJ.Nat Chem Biolhttps://doi.org/10.1038/s41589-025-01893-5
2025Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregatesYan X, Kuster D, Mohanty P, Nijssen J, Pombo-García K, Garcia Morato J, Rizuan A, Franzmann TM, Sergeeva A, Ly AM, Liu F, Passos PM, George L, Wang SH, Shenoy J, Danielson HL, Ozguney B, Honigmann A, Ayala YM, Fawzi NL, Dickson DW, Rossoll W, Mittal J, Alberti S, Hyman AA.Cellhttps://doi.org/10.1016/j.cell.2025.04.039
2025Assembly of tight junction belts by ZO1 surface condensation and local actin polymerizationSun D, Zhao X, Wiegand T, Martin-Lemaitre C, Borianne T, Kleinschmidt L, Grill SW, Hyman AA, Weber C, Honigmann A.Dev Cellhttps://doi.org/10.1016/j.devcel.2024.12.012
2025Author Correction: An endosomal tether undergoes an entropic collapse to bring vesicles togetherMurray DH, Jahnel M, Lauer J, Avellaneda MJ, Brouilly N, Cezanne A, Morales-Navarrete H, Perini ED, Ferguson C, Lupas AN, Kalaidzidis Y, Parton RG, Grill SW, Zerial M.Naturehttps://doi.org/10.1038/s41586-024-08567-7
2025Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular CondensatesHe Z, Sommer JU, Harmon TS.ACS Macro Letthttps://doi.org/10.1021/acsmacrolett.4c00821
2025SHARK-capture identifies functional motifs in intrinsically disordered protein regionsChow CFW, Lenz S, Scheremetjew M, Ghosh S, Richter D, Jegers C, von Appen A, Alberti S, Toth-Petroczy A.Protein Scihttps://doi.org/10.1002/pro.70091
2024PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA endsChappidi N, Quail T, Doll S, Vogel LT, Aleksandrov R, Felekyan S, Kühnemuth R, Stoynov S, Seidel CAM, Brugués J, Jahnel M, Franzmann TM, Alberti S.Cellhttps://doi.org/10.1016/j.cell.2024.01.015
2024Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregatesYan X, Kuster D, Mohanty P, Nijssen J, Pombo-García K, Rizuan A, Franzmann TM, Sergeeva A, Passos PM, George L, Wang SH, Shenoy J, Danielson HL, Honigmann A, Ayala YM, Fawzi NL, Mittal J, Alberti S, Hyman AA.bioRxivhttps://doi.org/10.1101/2024.01.23.576837
2024Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALSPal A, Grossmann D, Glaß H, Zimyanin V, Günther R, Catinozzi M, Boeckers TM, Sterneckert J, Storkebaum E, Petri S, Wegner F, Grill SW, Pan-Montojo F, Hermann A.Life Sci Alliancehttps://doi.org/10.26508/lsa.202302535
2024eIF4F is a thermo-sensing regulatory node in the translational heat shock responseDesroches Altamirano C, Kang MK, Jordan MA, Borianne T, Dilmen I, Gnädig M, von Appen A, Honigmann A, Franzmann TM, Alberti S.Mol Cellhttps://doi.org/10.1016/j.molcel.2024.02.038
2024Droplet Differentiation by a Chemical SwitchChen X, Seyboldt R, Sommer JU, Jülicher F, Harmon T.Phys Rev Letthttps://doi.org/10.1103/PhysRevLett.133.028402
2024PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organismsHadarovich A, Singh HR, Ghosh S, Scheremetjew M, Rostam N, Hyman AA, Toth-Petroczy A.Nat Communhttps://doi.org/10.1038/s41467-024-55089-x
2024Actin polymerization counteracts prewetting of N-WASP on supported lipid bilayersWiegand T, Liu J, Vogeley L, LuValle-Burke I, Geisler J, Fritsch AW, Hyman AA, Grill SW.Proc Natl Acad Sci U S Ahttps://doi.org/10.1073/pnas.2407497121
2024A self-organised liquid reaction container for cellular memory S Mukherjee, E Skoruppa, H Merlitz, JU Sommer, H SchiesselarXivhttps://doi.org/10.48550/arXiv.2412.15394
2023CD-CODE: crowdsourcing condensate database and encyclopediaRostam N, Ghosh S, Chow CFW, Hadarovich A, Landerer C, Ghosh R, Moon H, Hersemann L, Mitrea DM, Klein IA, Hyman AA, Toth-Petroczy A.Nat Methodshttps://doi.org/10.1038/s41592-023-01831-0
2022Surface Electrostatics Govern the Emulsion Stability of Biomolecular CondensatesWelsh TJ, Krainer G, Espinosa JR, Joseph JA, Sridhar A, Jahnel M, Arter WE, Saar KL, Alberti S, Collepardo-Guevara R, Knowles TPJ.Nano Letthttps://doi.org/10.1021/acs.nanolett.1c03138
2022Biomolecular condensate phase diagrams with a combinatorial microdroplet platformArter WE, Qi R, Erkamp NA, Krainer G, Didi K, Welsh TJ, Acker J, Nixon-Abell J, Qamar S, Guillén-Boixet J, Franzmann TM, Kuster D, Hyman AA, Borodavka A, George-Hyslop PS, Alberti S, Knowles TPJ.Nat Communhttps://doi.org/10.1038/s41467-022-35265-7
2022Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutionsKar M, Dar F, Welsh TJ, Vogel LT, Kühnemuth R, Majumdar A, Krainer G, Franzmann TM, Alberti S, Seidel CAM, Knowles TPJ, Hyman AA, Pappu RV.Proc Natl Acad Sci U S Ahttps://doi.org/10.1073/pnas.2202222119
2022SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNAMaharana S, Kretschmer S, Hunger S, Yan X, Kuster D, Traikov S, Zillinger T, Gentzel M, Elangovan S, Dasgupta P, Chappidi N, Lucas N, Maser KI, Maatz H, Rapp A, Marchand V, Chang YT, Motorin Y, Hubner N, Hartmann G, Hyman AA, Alberti S, Lee-Kirsch MA.Mol Cellhttps://doi.org/10.1016/j.molcel.2022.08.031
2022Polymer-assisted condensation: A mechanism for hetero-chromatin formation and epigenetic memorySommer JU, Merlitz H, Schiessel HMacromoleculeshttps://doi.org/10.1021/acs.macromol.2c00244
2021Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageingAlberti S, Hyman AA.Nat Rev Mol Cell Biolhttps://doi.org/10.1038/s41580-020-00326-6
2021Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1)Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, et al.Autophagyhttps://doi.org/10.1080/15548627.2020.1797280
2021Adaptable P body physical states differentially regulate bicoid mRNA storage during early Drosophila developmentSankaranarayanan M, Emenecker RJ, Wilby EL, Jahnel M, Trussina IREA, Wayland M, Alberti S, Holehouse AS, Weil TT.Dev Cellhttps://doi.org/10.1016/j.devcel.2021.09.021
2021Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signalingMediani L, Antoniani F, Galli V, Vinet J, Carrà AD, Bigi I, Tripathy V, Tiago T, Cimino M, Leo G, Amen T, Kaganovich D, Cereda C, Pansarasa O, Mandrioli J, Tripathi P, Troost D, Aronica E, Buchner J, Goswami A, Sterneckert J, Alberti S, Carra S.EMBO Rephttps://doi.org/10.15252/embr.202051740
2021Thermal fluctuations assist mechanical signal propagation in coiled-coil proteinsClopés J, Shin J, Jahnel M, Grill SW, Zaburdaev V.Phys Rev Ehttps://doi.org/10.1103/PhysRevE.104.054403
2021HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domainBoczek EE, Fürsch J, Niedermeier ML, Jawerth L, Jahnel M, Ruer-Gruß M, Kammer KM, Heid P, Mediani L, Wang J, Yan X, Pozniakovski A, Poser I, Mateju D, Hubatsch L, Carra S, Alberti S, Hyman AA, Stengel F.Elifehttps://doi.org/10.7554/eLife.69377
2021Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactionsKrainer G, Welsh TJ, Joseph JA, Espinosa JR, Wittmann S, de Csilléry E, Sridhar A, Toprakcioglu Z, Gudiškytė G, Czekalska MA, Arter WE, Guillén-Boixet J, Franzmann TM, Qamar S, George-Hyslop PS, Hyman AA, Collepardo-Guevara R, Alberti S, Knowles TPJ.Nat Communhttps://doi.org/10.1038/s41467-021-21181-9
2020RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by CondensationGuillén-Boixet J, Kopach A, Holehouse AS, Wittmann S, Jahnel M, Schlüßler R, Kim K, Trussina IREA, Wang J, Mateju D, Poser I, Maharana S, Ruer-Gruß M, Richter D, Zhang X, Chang YT, Guck J, Honigmann A, Mahamid J, Hyman AA, Pappu RV, Alberti S, Franzmann TM.Cellhttps://doi.org/10.1016/j.cell.2020.03.049
2020Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein ProductionIserman C, Desroches Altamirano C, Jegers C, Friedrich U, Zarin T, Fritsch AW, Mittasch M, Domingues A, Hersemann L, Jahnel M, Richter D, Guenther UP, Hentze MW, Moses AM, Hyman AA, Kramer G, Kreysing M, Franzmann TM, Alberti S.Cellhttps://doi.org/10.1016/j.cell.2020.04.009
2020Erratum: Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps [Phys. Rev. Lett. 121, 258101 (2018)]Jawerth LM, Ijavi M, Ruer M, Saha S, Jahnel M, Hyman AA, Jülicher F, Fischer-Friedrich E.Phys Rev Letthttps://doi.org/10.1103/PhysRevLett.125.229901
2019Soluble tubulin is significantly enriched at mitotic centrosomesBaumgart J, Kirchner M, Redemann S, Bond A, Woodruff J, Verbavatz JM, Jülicher F, Müller-Reichert T, Hyman AA, Brugués J.J Cell Biolhttps://doi.org/10.1083/jcb.201902069
2019FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagyMarrone L, Drexler HCA, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson EN, Kour S, Moraiti A, Maharana S, Bhatnagar R, Belgard TG, Tripathy V, Kalmbach N, Hosseinzadeh Z, Crippa V, Abo-Rady M, Wegner F, Poletti A, Troost D, Aronica E, Busskamp V, Weis J, Pandey UB, Hyman AA, Alberti S, Goswami A, Sterneckert J.Acta Neuropatholhttps://doi.org/10.1007/s00401-019-01998-x
2018A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding ProteinsWang J, Choi JM, Holehouse AS, Lee HO, Zhang X, Jahnel M, Maharana S, Lemaitre R, Pozniakovsky A, Drechsel D, Poser I, Pappu RV, Alberti S, Hyman AA.Cellhttps://doi.org/10.1016/j.cell.2018.06.006
2018A User's Guide for Phase Separation Assays with Purified ProteinsAlberti S, Saha S, Woodruff JB, Franzmann TM, Wang J, Hyman AA.J Mol Biolhttps://doi.org/10.1016/j.jmb.2018.06.038
2018RNA buffers the phase separation behavior of prion-like RNA binding proteinsMaharana S, Wang J, Papadopoulos DK, Richter D, Pozniakovsky A, Poser I, Bickle M, Rizk S, Guillén-Boixet J, Franzmann TM, Jahnel M, Marrone L, Chang YT, Sterneckert J, Tomancak P, Hyman AA, Alberti S.Sciencehttps://doi.org/10.1126/science.aar7366
2018Protein Dynamics in Complex DNA LesionsAleksandrov R, Dotchev A, Poser I, Krastev D, Georgiev G, Panova G, Babukov Y, Danovski G, Dyankova T, Hubatsch L, Ivanova A, Atemin A, Nedelcheva-Veleva MN, Hasse S, Sarov M, Buchholz F, Hyman AA, Grill SW, Stoynov SS.Mol Cellhttps://doi.org/10.1016/j.molcel.2018.02.016
2018Phase separation of a yeast prion protein promotes cellular fitnessFranzmann TM, Jahnel M, Pozniakovsky A, Mahamid J, Holehouse AS, Nüske E, Richter D, Baumeister W, Grill SW, Pappu RV, Hyman AA, Alberti S.Sciencehttps://doi.org/10.1126/science.aao5654
2018Non-invasive perturbations of intracellular flow reveal physical principles of cell organizationMittasch M, Gross P, Nestler M, Fritsch AW, Iserman C, Kar M, Munder M, Voigt A, Alberti S, Grill SW, Kreysing M.Nat Cell Biolhttps://doi.org/10.1038/s41556-017-0032-9
2018Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing AutophagyMarrone L, Poser I, Casci I, Japtok J, Reinhardt P, Janosch A, Andree C, Lee HO, Moebius C, Koerner E, Reinhardt L, Cicardi ME, Hackmann K, Klink B, Poletti A, Alberti S, Bickle M, Hermann A, Pandey UB, Hyman AA, Sterneckert JL.Stem Cell Reportshttps://doi.org/10.1016/j.stemcr.2017.12.018
2018Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formationNaumann M, Pal A, Goswami A, Lojewski X, Japtok J, Vehlow A, Naujock M, Günther R, Jin M, Stanslowsky N, Reinhardt P, Sterneckert J, Frickenhaus M, Pan-Montojo F, Storkebaum E, Poser I, Freischmidt A, Weishaupt JH, Holzmann K, Troost D, Ludolph AC, Boeckers TM, Liebau S, Petri S, Cordes N, Hyman AA, Wegner F, Grill SW, Weis J, Storch A, Hermann A.Nat Communhttps://doi.org/10.1038/s41467-017-02299-1
2018Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and RecoveryKroschwald S, Munder MC, Maharana S, Franzmann TM, Richter D, Ruer M, Hyman AA, Alberti S.Cell Rephttps://doi.org/10.1016/j.celrep.2018.05.041
2018Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical TrapsJawerth LM, Ijavi M, Ruer M, Saha S, Jahnel M, Hyman AA, Jülicher F, Fischer-Friedrich E.Phys Rev Letthttps://doi.org/10.1103/PhysRevLett.121.258101
2017ATP as a biological hydrotropePatel A, Malinovska L, Saha S, Wang J, Alberti S, Krishnan Y, Hyman AA.Sciencehttps://doi.org/10.1126/science.aaf6846
2017Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau PhaseHernández-Vega A, Braun M, Scharrel L, Jahnel M, Wegmann S, Hyman BT, Alberti S, Diez S, Hyman AA.Cell Rephttps://doi.org/10.1016/j.celrep.2017.08.042
2017The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating TubulinWoodruff JB, Ferreira Gomes B, Widlund PO, Mahamid J, Honigmann A, Hyman AA.Cellhttps://doi.org/10.1016/j.cell.2017.05.028
2017An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone functionMateju D, Franzmann TM, Patel A, Kopach A, Boczek EE, Maharana S, Lee HO, Carra S, Hyman AA, Alberti S.EMBO Jhttps://doi.org/10.15252/embj.201695957
2016Mechanisms of backtrack recovery by RNA polymerases I and IILisica A, Engel C, Jahnel M, Roldán É, Galburt EA, Cramer P, Grill SW.Proc Natl Acad Sci U S Ahttps://doi.org/10.1073/pnas.1517011113
2016An endosomal tether undergoes an entropic collapse to bring vesicles togetherMurray DH, Jahnel M, Lauer J, Avellaneda MJ, Brouilly N, Cezanne A, Morales-Navarrete H, Perini ED, Ferguson C, Lupas AN, Kalaidzidis Y, Parton RG, Grill SW, Zerial M.Naturehttps://doi.org/10.1038/nature19326
2016Amyloid-like Self-Assembly of a Cellular CompartmentBoke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ.Cellhttps://doi.org/10.1016/j.cell.2016.06.051
2016Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition MechanismSaha S, Weber CA, Nousch M, Adame-Arana O, Hoege C, Hein MY, Osborne-Nishimura E, Mahamid J, Jahnel M, Jawerth L, Pozniakovski A, Eckmann CR, Jülicher F, Hyman AA.Cellhttps://doi.org/10.1016/j.cell.2016.08.006
2016Are aberrant phase transitions a driver of cellular aging?Alberti S, Hyman AA.Bioessayshttps://doi.org/10.1002/bies.201600042
2015A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease MutationPatel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S.Cellhttps://doi.org/10.1016/j.cell.2015.07.047
2015Temperature Dependence of Cell Division Timing Accounts for a Shift in the Thermal Limits of C. elegans and C. briggsaeBegasse ML, Leaver M, Vazquez F, Grill SW, Hyman AA.Cell Rephttps://doi.org/10.1016/j.celrep.2015.01.006
2011Measuring the complete force field of an optical trapJahnel M, Behrndt M, Jannasch A, Schäffer E, Grill SW.Opt Letthttps://doi.org/10.1364/OL.36.001260
2011PAR proteins diffuse freely across the anterior-posterior boundary in polarized C. elegans embryosGoehring NW, Hoege C, Grill SW, Hyman AA.J Cell Biolhttps://doi.org/10.1083/jcb.201011094
2011Polarization of PAR proteins by advective triggering of a pattern-forming systemGoehring NW, Trong PK, Bois JS, Chowdhury D, Nicola EM, Hyman AA, Grill SW.Sciencehttps://doi.org/10.1126/science.1208619
2010FRAP analysis of membrane-associated proteins: lateral diffusion and membrane-cytoplasmic exchangeGoehring NW, Chowdhury D, Hyman AA, Grill SW.Biophys Jhttps://doi.org/10.1016/j.bpj.2010.08.033