DateGroupsTitleJournal 2022Grill, Jülicher A condensate dynamic instability orchestrates actomyosin cortex activationNature 2022Jülicher Chemical Kinetics and Mass Action in Coexisting PhasesJ Am Chem Soc 2021Alberti Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiaeJ Biol Chem 2021Alberti Adaptable P body physical states differentially regulate bicoid mRNA storage during early Drosophila developmentDev Cell 2022Alberti, Jahnel Surface Electrostatics Govern the Emulsion Stability of Biomolecular CondensatesNano Lett 2022Alberti Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificityElife 2022Alberti CAPRIN1P512L causes aberrant protein aggregation and associates with early-onset ataxiaCellular and Molecular Life Sciences 2022Alberti, Hyman Biomolecular condensate phase diagrams with a combinatorial microdroplet platformNat Comm 2022Alberti Cytosolic stress granules relieve the ubiquitin-proteasome system in the nuclear compartment EMBO J 2022Alberti, Hyman Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutionsPNAS 2022Alberti, HymanSAMHD1 controls innate immunity by regulating condensation of immunogenic self RNAMol Cell 2021Honigmann, Jülicher Transcription organizes euchromatin via microphase separationNat Comm 2021Diez The ALS-Associated FUS (P525L) Variant Does Not Directly Interfere with Microtubule-Dependent Kinesin-1 MotilityInt. J. Mol. Sci. 2020Alberti ALS and FTD: Where RNA metabolism meets protein quality controlSemin Cell Dev Biol 2020Alberti, PiginoReorganization of budding yeast cytoplasm upon energy depletionMol Biol Cell 2020AlbertiBiomolecular condensates undergo a generic shear-mediated liquid-to-solid transitionNat Nanotechnol 2020AlbertiBAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomesCell Stress Chaperones 2020AlbertiThe Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress GranulesMol Cell 2020AlbertiThe plant response to heat requires phase separationNature 2020AlbertiProtein phase separation and its role in tumorigenesisElife 2020Tang Reversible pH-Responsive Coacervate Formation in Lipid Vesicles Activates Dormant Enzymatic ReactionsAngewandte Chemie Int Ed Engl 2020Alberti, PiginoFilament formation by the translation factor eIF2B regulates protein synthesis in starved cellsBiol Open 2020Hyman, JülicherProtein condensates as aging Maxwell fluidsScience 2020KreysingRegulated changes in material properties underlie centrosome disassembly during mitotic exitJ Cell Biol 2020Alberti, Hyman, KreysingCondensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein ProductionCell 2020Diez Cytoskeletal organization through multivalent interactionsJ Cell Sci 2020Alberti, Guck, Honigmann, Hyman RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by CondensationCell 2020HymanPartitioning of cancer therapeutics in nuclear condensatesScience 2020Honigmann, Hyman, Jülicher, ZechnerPhase separation provides a mechanism to reduce noise in cellsScience 2020Tang High-Throughput Synthesis and Screening of Functional Coacervates Using MicrofluidicsChemSystemsChem 2019Alberti Small heat shock proteins: multifaceted proteins with important implications for lifeCell Stress Chaperones 2019Alberti, HymanFUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagyActa Neuropathologica 2019Alberti Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitinEMBO J 2019AlbertiProteome-wide signatures of function in highly diverged intrinsically disordered regionsElife 2019Diez, HymanKinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymesNat Cell Biol 2019Alberti Prion-like low-complexity sequences: Key regulators of protein solubility and phase behaviorJ Biol Chem 2019Alberti Protein Phase Separation as a Stress Survival StrategyCold Spring Harb Perspect Biol 2019AlbertiLiquid-Liquid Phase Separation in DiseaseAnnu Rev Genet 2019Hyman, Tang Directed Growth of Biomimetic MicrocompartmentsAdvanced Biosystems 2019AlbertiNucleolus: A Liquid Droplet Compartment for Misbehaving ProteinsCurr Biol 2019KreysingMaterial aging causes centrosome weakening and disassembly during mitotic exitbioRxiv (preprint) 2019Tang Microfluidic Tools for Bottom-Up Synthetic CellularityChem 2019Alberti The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivoNat Commun 2019Brugués, Hyman, JülicherSoluble tubulin is significantly enriched at mitotic centrosomesJ Cell Biol 2019KreysingProbing the Functional Role of Physical Motion in DevelopmentDevelopmental Cell 2019Alberti Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular CondensatesCell 2019AlbertiNucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteinsMol Cell Oncol 2019Honigmann Phase Separation of Zonula Occludens Proteins Drives Formation of Tight JunctionsCell 2018Hyman Organization and Function of Non-dynamic Biomolecular CondensatesTrends Biochem Sci 2018Tang Microfluidic formation of proteinosomesChem Commun (Camb) 2018AlbertiQuality Control of Membraneless OrganellesJ Mol Biol 2018Alberti, Hyman A User's Guide for Phase Separation Assays with Purified ProteinsJ Mol Biol 2018Hyman Phase Transitions Drive the Formation of Vesicular Stomatitis Virus Replication CompartmentsmBio 2018Alberti, Grill, Hyman Phase separation of a yeast prion protein promotes cellular fitnessScience 2018Kreysing, TangCompartmentalised RNA catalysis in membrane-free coacervate protocellsNat Commun 2018Hyman Controlling compartmentalization by non-membrane-bound organellesPhilos Trans R Soc Lond B Biol Sci 2018Hyman PLK4 is a microtubule-associated protein that self-assembles promoting de novo MTOC formationJ Cell Sci 2018Alberti Phase changes in neurotransmissionScience 2018Hyman Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cellsEMBO J 2018KreysingAcetylation of intrinsically disordered regions regulates phase separationNat Chem Biol 2018Hyman, Tang MaxSynBio: Avenues Towards Creating Cells from the Bottom UpAngewendete Chemie Int Ed Engl 2018Alberti, HymanDifferent Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery Cell Rep 2018Hyman, Jülicher Positioning of Particles in Active DropletsPhysical Review Letters 2018Alberti, Hyman Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing AutophagyStem Cell Reports 2018Alberti Phase shifts in protein folding space: links to stress adaptation and diseaseMol Biol Cell 2018Hyman, JülicherSalt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical TrapsPhysical Review Letters 2018Hyman Tau protein liquid-liquid phase separation can initiate tau aggregationEMBO J 2018Grill, Hyman Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formationNat Commun 2018Alberti, Hyman RNA buffers the phase separation behavior of prion-like RNA binding proteinsScience 2018Alberti, Hyman A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding ProteinsCell 2018Alberti Protein Phase Separation: A New Phase in Cell BiologyTrends Cell Biol 2018HymanOrganization and Function of Non-dynamic Biomolecular CondensatesTrends Biochem Sci 2017HymanBiomolecular condensates: organizers of cellular biochemistryNat Rev Mol Cell Biol 2017Hyman, AlbertiATP as a biological hydrotropeScience 2017Hyman, HonigmannThe Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating TubulinCell 2017Hyman, AlbertiAn aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone functionEMBO J 2017HymanRNA gets in phaseJ Cell Biol 2017Hyman, Alberti, DiezLocal Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau PhaseCell Rep 2017Hyman, Alberti, GrillPhase separation of a yeast prion protein promotes cellular fitnessScience 2016Tang Polynucleotides in cellular mimics: Coacervates and lipid vesiclesCurrent Opinion in Colloid & Interface Science 2016HymanKi-67 acts as a biological surfactant to disperse mitotic chromosomesNature 2016Hyman, AlbertiAmyloid-like Self-Assembly of a Cellular CompartmentCell 2016Hyman, JülicherPolar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition MechanismCell 2016Hyman, AlbertiAre aberrant phase transitions a driver of cellular aging?Bioessays 2015Tang Microfluidic Formation of Membrane-Free Aqueous Coacervate Droplets in WaterAngewandte Chemie Int Ed Engl 2015Tang In vitro gene expression within membrane-free coacervate protocellsChem Commun (Camb) 2015HymanCentrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitroScience 2015Hyman, JülicherSuppression of Ostwald ripening in active emulsionsPhys Rev E 2015Alberti, Hyman, Grill, Jülicher,A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease MutationCell 2014Tang Synthetic cellularity based on non-lipid micro-compartments and protocell modelsCurr Opin Chem Biol 2014Tang Fatty acid membrane assembly on coacervate microdroplets as a step towards a hybrid protocell modelNature Chem 2014Hyman, JülicherLiquid-liquid phase separation in biologyAnnu Rev Cellbio 2013AlbertiProtein disorder, prion propensities, and self-organizing macromolecular collectivesBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2013Tang Small-molecule uptake in membrane-free peptide/nucleotide protocellsSoft Matter 2012Alberti Prion formation by a yeast GLFG nucleoporinPrion 2012Alberti Molecular mechanisms of spatial protein quality controlPrion 2012Alberti Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregatesMolecular Biology of the Cell 2012HymanACell biology. Beyond oil and water--phase transitions in cellsScience 2011Alberti Opposing Effects of Glutamine and Asparagine Govern Prion Formation by Intrinsically Disordered ProteinsMolecular Cell 2011HymanBeyond stereospecificity: liquids and mesoscale organization of cytoplasmDevelopmental Cell 2011HymanActive liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytesPNAS 2010Alberti Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeastMethods in enzymology 2010Alberti Prions, protein homeostasis, and phenotypic diversityTrends Cell Biol 2009Hyman, JülicherGermline P granules are liquid droplets that localize by controlled dissolution/condensationScience
