The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUS
What drives the formation of biomolecular condensates from proteins in water? The Adams group, in collaboration with colleagues from Ruhr-University Bochum, Germany, measured the thermodynamic forces leading to the expulsion of water from condensates as they form through protein-protein interactions. the results are published in the Biophysical Journal. Read more.

Current news by our research groups
Agnes Toth-Petroczy Group,Anthony Hyman Group
CD-Code is now published in Nature Methods
CD-CODE is now published in Nature Methods. It is a “living database” that we designed for fast…
Marcus Jahnel Group,Simon Alberti Group,Alf Honigmann Group,Anthony Hyman Group
A role for RNA in Stress Granules assembly
Stress granules are membraneless compartments formed by phase separation of specific molecules upon exposure to cellular stress such as oxidative stress, heat shock, or osmotic stress. The Alberti, Jahnel, Honigmann, and Hyman labs published a study in cell highlighting the role of RNA in the…
Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells
Aminoacyl-tRNA synthetases (aaRSs), the enzymes responsible for coupling tRNAs to their cognate amino acids, minimize translational errors by intrinsic hydrolytic editing. Here, we compared norvaline (Nva), a linear amino acid not coded for protein synthesis, to the proteinogenic, branched valine…
Moritz Kreysing Group,Simon Alberti Group,Anthony Hyman Group
Condensation regulates translation
New insights into the influence of Ded1p condensation on translation comes from the Hyman, Alberti and Kreysing labs. The study published in Cell is entitled "Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production".
Graphical abstract: