Researchers from Dresden and Barcelona reveal how glycolysis drives early embryonic cell decisions
The studies, published in CellStemCell, uncover the instructive potential of glycolysis. Read the press coverage and publications for more:
- https://www.embl.org/news/science-technology/metabolism-shapes-life/
- https://www.mpi-cbg.de/news-outreach/news-media/article/metabolism-shapes-life
- Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model. Cell Stem Cell, 16 April, 2025. https://doi.org/10.1016/j.stem.2025.03.012
- Glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling, Cell Stem Cell (2025). https://doi.org/10.1016/j.stem.2025.03.011
Current news by our research groups
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates
A new study from the labs of Honigmann, Hyman, and Alberti in Dresden, in addition to colleagues in Texas A&M University, Mayo Clinic, Brown University, and Saint Louis University investigates the mechanism behind pathological outcomes of protein aggregation inside stress granules. The authors…
Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates
A new Study from the Harmon and Sommer Labs in ACS Macro Letters entitled 'Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates' addressed how the geometry and structure of folded domains impact condensate formation. They used coarse-grained simulations to determine that…
New Research Training Group for Biomolecular Condensates in Dresden
The DFG approved a funding application to establish a new Research Training Group (RTG 3120) in Dresden to train PhD students interdisciplinary methods and approaches to study Biomolecular Condensates. Read the press releases for more:…
CD-Code is now published in Nature Methods
CD-CODE is now published in Nature Methods. It is a “living database” that we designed for fast…
A role for RNA in Stress Granules assembly
Stress granules are membraneless compartments formed by phase separation of specific molecules upon exposure to cellular stress such as oxidative stress, heat shock, or osmotic stress. The Alberti, Jahnel, Honigmann, and Hyman labs published a study in cell highlighting the role of RNA in the…
Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells
Aminoacyl-tRNA synthetases (aaRSs), the enzymes responsible for coupling tRNAs to their cognate amino acids, minimize translational errors by intrinsic hydrolytic editing. Here, we compared norvaline (Nva), a linear amino acid not coded for protein synthesis, to the proteinogenic, branched valine…
Condensation regulates translation
New insights into the influence of Ded1p condensation on translation comes from the Hyman, Alberti and Kreysing labs. The study published in Cell is entitled "Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production".
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