20. August 2025
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates
A new study from the labs of Honigmann, Hyman, and Alberti in Dresden, in addition to colleagues in Texas A&M University, Mayo Clinic, Brown University, and Saint Louis University investigates the mechanism behind pathological outcomes of protein aggregation inside stress granules. The authors…
20. August 2025
Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates
A new Study from the Harmon and Sommer Labs in ACS Macro Letters entitled 'Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates' addressed how the geometry and structure of folded domains impact condensate formation. They used coarse-grained simulations to determine that…
9. July 2025
Researchers from Dresden and Barcelona reveal how glycolysis drives early embryonic cell decisions
The studies, published in CellStemCell, uncover the instructive potential of glycolysis. Read the press coverage and publications for more:
Metabolism shapes lifehttps://www.mpi-cbg.de/news-outreach/news-media/article/metabolism-shapes-life Integrated…
30. November 2022
Molecular Assembly Lines in Active Droplets
Cells assemble structures that have lots of molecules. How can such complicated structures be reliably assembled? We propose that cells could be organizing an assembly line process for the construction. We show how this could be organized inside droplets. In this video we explain our recent…
6. April 2021
The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUS
What drives the formation of biomolecular condensates from proteins in water? The Adams group, in collaboration with colleagues from Ruhr-University Bochum, Germany, measured the thermodynamic forces leading to the expulsion of water from condensates as they form through protein-protein…
28. February 2021
The ALS-Associated FUS (P525L) Variant Does Not Directly Interfere with Microtubule-Dependent Kinesin-1 Motility
The Diez lab, in collaboration with the Hermann lab in Rostock, Germany, have utilised an in vitro microtubule gliding motility assay to study deficient intracellular transport in motor neurons. The findings exclude a role of mutations in the phase-separating FUS protein, known to be mutated in…
15. June 2020
Cytoskeletal organization through multivalent interactions
Stefan Diez and collaborators Zdenek Lansky and Marcus Braun from the Institute of Biotechnology of the Czech Academy of Sciences, Czech Republic, published an Opinion article emphasizing the role of multivalent interactions cytoskeletal phenomena including (1) the generation of entropic forces by…
2. July 2019
Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes
The Diez and Hyman labs, in collaboration with the Lansky and Braun lab at the Institute of Biotechnology of the Czech Academy of Sciences, Czech Republic, published a study on the role of phase separation of the intrinsically disordered Tau protein in regulating the activity of motor proteins and…