Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

The Diez and Hyman labs, in collaboration with the Lansky and Braun lab at the Institute of Biotechnology of the Czech Academy of Sciences, Czech Republic, published a study on the role of phase separation of the intrinsically disordered Tau protein  in regulating the activity of motor proteins and severing enzymes on microtubules. The study, published in Nature Cell Biology demonstrated using in vitro protein reconstitution that Tau protects microtubules from degradation by forming reversible cohesive islands.

Tau islands constitute a protective layer around microtubules