Remodeling enzymes set up the canonical nucleosome organization of genes.
In an ATP hydrolysis-dependent manner, remodelers open up a “nucleosome depleted region” (NDR) and generate an array of nucleosomes with even spacing downstream of the transcription start site (arrow; bottom). Without remodelers (top), cryptic promoters open up leading to spurious transcription. Picture credits: Felix Mueller-Planitz
