© Physics of Life TU Dresden

The molecular world, where nothing ever stands still, poses some intriguing challenges to our understanding of living matter. How do molecules robustly self-organize into cellular compartments, transmit signals or generate forces in the omnipresence of thermal fluctuations? How are decisions made reliably on that level? And how can tiny molecular changes lead to significant effects for an organism on different length and time scales?

Research Focus

Our team works at the intersection of molecular cell biology and polymer physics, and we are fascinated by the emergent molecular behavior of Life’s building blocks. We see proteins and RNAs as multifaceted actors that readily adopt roles as information carriers, as structural materials, as complex fluids, as molecular thermometers, as choreographers, as timekeepers, soft machines, and sometimes all at once. This fascinating molecular universe offers a rich playground to expand both our understanding of physics and biology.

To investigate the dynamic nature of Life’s molecules, we employ a captivating property of light: it can be used to exert and measure minute forces, forces so small that it allows us to study and manipulate individual molecular players with precision. In essence, we use the Physics of Light to study the Physics of Life.


Current news by this research group

Join us as a Postdoc to develop Smart Optical Tweezers to Probe Biomolecular Condensates

The Marcus Jahnel group for Dynamics of Biomolecules at the Cluster of Excellence "Physics of Life" and BIOTEC center, TU Dresden, are recruiting a Research Associate / Postdoc (m/f/x) to study RNA folding and RNA looping in biomolecular condensates. For more details and instructions to apply,…

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Join us as a Postdoc to study RNA Biology in Biomolecular Condensates

The Marcus Jahnel group for Dynamics of Biomolecules at the Cluster of Excellence "Physics of Life" and BIOTEC center, TU Dresden, are recruiting a Research Associate / Postdoc (m/f/x) to start immediately to study RNA folding and RNA looping in biomolecular condensates. For more details and…

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Physics of Life Excellence Postdoctoral Fellowships

Join research groups at the Physics of Life (PoL) as a postdoc by applying to a PoL Excellence Postdoctoral Fellowship and benefit from up to 4-year funded position in association with PoL groups and the Mentorship program. Applicants should hold a PhD in Physics, Biology or related fields (at the…

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A role for RNA in Stress Granules assembly

Stress granules are membraneless compartments formed by phase separation of specific molecules upon exposure to cellular stress such as oxidative stress, heat shock, or osmotic stress. The Alberti, Jahnel, Honigmann, and Hyman labs published a study in cell highlighting the role of RNA in the…

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Local nucleation of microtubule bundles through tubulin concentration into a condensed tau phase

Theskeleton that supports the structure of our cells, termed cytoskeleton is formed of several kinds of polymers including actin and microtubules. How the single units on the polymers (monomers and dimers) are concentrated to gether to synthesize the polymer is the subject of this study by the labs…

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