A quick intro to the Phase Diagram
Phase Diagrams are graphic representations that help understand many physical systems such as magnets and pure substances like water. These diagrams also help us understand how dense droplets of biomolecules, called Biomolecular Condensates, form inside cells. Phase Diagrams predict under which conditions these condensates can form and also what will be their molecular concentration. Watch this quick intro to learn more! References: -Video C. Elegans: Fritsch, Diaz-Delgadillo, Adame-Arana et al., PNAS (2021) https://www.pnas.org/doi/10.1073/pnas… -Multicomponent Phase Diagram: Bauerman, Laha, McCall, and Weber JACS (2022) https://pubs.acs.org/doi/pdf/10.1021/…
Prepared by Mariona Esquerda Ciutat from the Hyman and Jülicher labs in Dresden.
Current news by our research groups
Agnes Toth-Petroczy Group,Anthony Hyman Group
CD-Code is now published in Nature Methods
CD-CODE is now published in Nature Methods. It is a “living database” that we designed for fast addition and review of information about condensates and proteins and is open to users and expert researchers who would like to contribute. Join us and visit cd-code! CD code has been a…
Computational Postdoc or PhD student (m/f/d) in protein evolution and biomolecular condensates
The Toth-Petroczy lab is an interdisciplinary research group at MPI-CBG and CSBD that studies protein evolution. Applications will be reviewed on a rolling basis until the position is filled. The Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the Center for Systems…
We are hiring a Software Developer
The Toth-Petroczy lab is an interdisciplinary research group at MPI-CBG and CSBD that studies protein evolution. Applications will be reviewed on a rolling basis until the position is filled. The Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the Center for…
Marcus Jahnel Group,Simon Alberti Group,Alf Honigmann Group,Anthony Hyman Group
A role for RNA in Stress Granules assembly
Stress granules are membraneless compartments formed by phase separation of specific molecules upon exposure to cellular stress such as oxidative stress, heat shock, or osmotic stress. The Alberti, Jahnel, Honigmann, and Hyman labs published a study in cell highlighting the role of RNA in the…
Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells
Aminoacyl-tRNA synthetases (aaRSs), the enzymes responsible for coupling tRNAs to their cognate amino acids, minimize translational errors by intrinsic hydrolytic editing. Here, we compared norvaline (Nva), a linear amino acid not coded for protein synthesis, to the proteinogenic, branched valine…
Moritz Kreysing Group,Simon Alberti Group,Anthony Hyman Group
Condensation regulates translation
New insights into the influence of Ded1p condensation on translation comes from the Hyman, Alberti and Kreysing labs. The study published in Cell is entitled "Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production". Graphical abstract: Abstract: Cells…