Molecular Assembly Lines in Active Droplets

  Cells assemble structures that have lots of molecules. How can such complicated structures be reliably assembled? We propose that cells could be organizing an assembly line process for the construction. We show how this could be organized inside droplets. In this video we explain our recent…

A quick intro to the Phase Diagram

Phase Diagrams are graphic representations that help understand many physical systems such as magnets and pure substances like water. These diagrams also help us understand how dense droplets of biomolecules, called Biomolecular Condensates, form inside cells. Phase Diagrams predict under which…

A quick intro to Entropy

Have you ever seen a tepid cup of coffee getting hot? Or a pile of sand grains organizing themselves into a sand castle? It would be strange, right? But why? The reason is behind one of the most fundamental and general laws of physics: The Second Law of Thermodynamics. Prepared by Mariona Esquerda…

A quick intro to the Second Law of Thermodynamics

Have you ever seen a tepid cup of coffee getting hot? Or a pile of sand grains organizing themselves into a sand castle? It would be strange, right? But why? The reason is behind one of the most fundamental and general laws of physics: The Second Law of Thermodynamics. Prepared by Mariona Esquerda…

Intro to Phase Separation

Ink and water mix but oil and water don’t. We all know this. But why? Mixing and demixing are relevant processes for many different systems: from the air, you breathe to metallic alloys on your car wheels, and to the smoothie on your breakfast. Recent research shows that these processes also take…

Biomolecular Condensates

In schoolbooks, cells are generally pictured as a membrane bubble full of smaller compartments also wrapped by a membrane. In reality, things differ from this simple picture. There are many compartments that are not bound by a membrane. Learn what they are and their amazing properties in this 2…

Centrosome Assembly

Hyman lab postdoc Jeff Woodruff describes the great unknowns of centrosome assembly and his plan of attack. Written and narrated by Jeff Woodruff. Produced by Lisa Dennison.

Phase Transition in Disease

In this video and the accompanying Cell paper, the Tony Hyman and Simon Alberti groups at Max Planck Institute propose an interesting idea that aging cells fail to maintain the liquid phase of ALS-associated protein FUS. The FUS liquid compartment instead forms disease-link solid phase…

Phase Transitions in Cells

Hyman lab postdoc Louise Jawerth tackles the phase transitions that occur within the cytoplasm. Written and narrated by Louise Jawerth. Produced by Lisa Dennison.

Phase separation in cell polarity

In this video abstract, Shamba Saha tells you about his recent publication in Cell, “Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism.” Learn more in the full paper Saha et al. (2016) published in Cell,…